. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: Sleep Med Rev. 2020 Mar 20;52:101313. doi: 10.1016/j.smrv.2020.101313

Table 1.

Description of and labels for the potysomnographic clusters based on distinguishing features.

Cluster (n)	Cluster label	Median AHI^a (events/h)	Conventional OSA severity^a
A (533)	Mild	4	None\mild
B (119)^*	PLMS	10
C (186)	NREM and poor sleep	19	Moderate
D (168)	REM and hypoxia	19
E (75)^*	Hypopnea and hypoxia	44	Severe
F (42)	Arousal and poor sleep	68
G (124)	Combined severe	84

AHI, apnea-hypopnea index: NREM, non-rapid eye movement: OSA, obstructive sleep apnea: PLMS, periodic limb movements of sleep: REM, rapid eye movement.

In regular CPAP users (vs. non-regular CPAP users) there was an attenuation in CV risk within the PLMS (cluster B) and hypopnea/hypoxia clusters (cluster E). Table reproduced with permission from Ref. [ 1 ].

OSA severity definitions: none/mild (AHI < 15). moderate (15 ≤ AHI < 30) and severe (AH ≥ 30). AHI was not used in generating patient clusters. Median AH Is and severity categories based on median AHI for each cluster are shown for descriptive purposes only (mean AHIs were 7.5, 13.6, 24.0, 25.0, 47.6, 72.6 and 82.4 for clusters A,B,C,D,E,F and G, respectively).