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Potencies of PeIA-5469 and PeIA-5441 for nAChR subtypes expressed in X. laevis oocytes
| IC50 values (nM) | ||||||||
|---|---|---|---|---|---|---|---|---|
| α3β2 | α3β4 | α4β2 | α4β4 | α6/α3β2β3 | α6/α3β4 | α7 | α9α10 | |
| PeIA-5469 | 8.5 (7.8–9.4) | >10,000 | >10,000 | >10,000 | 2,110 (1,250–3,581) | >10,000 | 6.5 (5.5–7.6) | >10,000 |
| PeIA-5441 | 1.9 (1.6–2.3) | 316 (253–394) | 548 (442–648) | >10,000 | 44.2 (39.2–49.7) | 77.7 (69.2–87.1) | 42.9 (37.8–48.7) | >10,000 |
Values in parentheses indicate the 95% CI.
