Table 2.
Differences in the Alterations of sFC of the S1 Cortex Between the LBLP and HCs Groups (Two-Sample t-Test, Two-Tailed, Voxel-Level P < 0.001, GRF Correction, Cluster-Level P < 0.005)
| Brain Regions | BA | Peak T-Scores |
MNI Coordinates | Cluster Size (Voxels) | zFC-values*(LBLP vs HCs) | Effect Size (Cohen’s d) | |||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| Seed: left S1back (LBLP vs HCs) | |||||||||
| Right superior and middle frontal gyrus (SFG/MFG) | 9, 10 | 5.498 | 30 | 27 | 36 | 130 | −0.008 ± 0.022 vs −0.175 ± 0.018 | 1.545 | |
| Seed: left S1chest (LBLP vs HCs) | |||||||||
| Right SFG/MFG | 8 | 4.345 | 30 | 24 | 39 | 109 | 0.005 ± 0.017 vs −0.146± 0.015 | 1.746 | |
| Seed: right S1chest (LBLP vs HCs) | |||||||||
| Right SFG/MFG | 10 | 4.707 | 36 | 48 | 27 | 99 | 0.070 ± 0.018 vs −0.083 ± 0.015 | 1.699 | |
| Seed: left S1face (LBLP vs HCs) | |||||||||
| Right MFG | 10 | 5.748 | 33 | 42 | 18 | 98 | 0.026 ± 0.019 vs −0.128 ± 0.019 | 1.519 | |
| Seed: right S1face (LBLP vs HCs) | |||||||||
| Right Inferior parietal lobule (IPL) | 40 | 5.487 | 60 | −39 | 27 | 89 | 0.123 ± 0.036 vs −0.087 ± 0.024 | 1.275 | |
Note: *mean ± standard error.
Abbreviations: LBLP, low-back-related leg pain; HCs, healthy controls; sFC, static functional connectivity; S1back, representation of the back in the primary somatosensory cortex; BA, Brodmann’s area; MNI, Montreal Neurological Institute Coordinate System.