Table 2.

Antibiotic Therapy and Clinical Outcomes of Patients with Post-Neurosurgical Enterobacteriaceae Meningitis/Encephalitis

Factors	Total (n=164)	Non-Survivor (n=38)	Survivor (n=126)	P
Antibiotic prophylaxis	148 (90.2%)	32 (84.2%)	116 (92.1%)	0.153
Ceftriaxone	39 (23.8%)	8 (21.1%)	31 (24.6%)	0.652
Ceftazidime	15 (9.1%)	3 (7.9%)	12 (9.5%)	0.76
Cefuroxime	51 (31.1%)	7 (18.4%)	44 (34.9%)	0.054
Meropenem	28 (17.1%)	8 (21.1%)	20 (15.9%)	0.457
Vancomycin	15 (9.1%)	6 (15.8%)	9 (7.1%)	0.105
Cefoperazone/Sulbactam	2 (1.2%)	0 (0.0%)	2 (1.6%)	0.435
Received empirical antibiotics	131 (79.9%)	32 (84.2%)	99 (78.6%)	0.447
Single antibiotics	26 (15.9%)	5 (13.2%)	21 (16.7%)	0.689
Ceftazidime	3 (1.8%)	0 (0.0%)	3 (2.4%)	0.337
Meropenem	17 (10.4%)	3 (7.9%)	14 (11.1%)	0.569
Cefuroxime	2 (1.2%)	0 (0.0%)	2 (1.6%)	0.435
Vancomycin	3 (1.8%)	1 (2.6%)	2 (1.6%)	0.674
Polymyxin	1 (0.6%)	1 (2.6%)	0 (0.0%)	0.068
Combination two antibiotics	90 (54.9%)	20 (12.2%)	60 (47.6%)	0.588
Vancomycin+Meropenem	75 (45.7%)	14 (8.5%)	61 (48.4%)	0.209
Meropenem+Ceftazidime	3 (1.8%)	1 (2.6%)	2 (1.6%)	0.674
Others	12 (7.3%)	5 (13.2%)	7 (5.6%)	0.115
Combination three antibiotics	15 (9.1%)	5 (13.2%)	10 (7.9%)	0.328
Vancomycin+Meropenem+Ceftazidime	12 (7.3%)	3 (7.9%)	9 (7.1%)	0.876
Others	3 (1.8%)	2 (5.3%)	1 (0.8%)	0.072
Received definitive therapy	137 (83.5%)	31 (81.6%)	106 (84.1%)	0.710
Single antibiotics	21 (12.8%)	2 (5.3%)	19 (15.1%)	0.112
Meropenem	19 (11.6%)	2 (5.3%)	17 (13.5%)	0.165
Vancomycin	2 (1.2%)	0 (0.0%)	2 (1.6%)	0.435
Combination two antibiotics	88 (53.7%)	15 (39.5%)	73 (57.9%)	0.673
Vancomycin+Meropenem	77 (47.0%)	14 (8.5%)	63 (50.0%)	0.154
Vancomycin+Ceftazidime	8 (4.9%)	1 (2.6%)	7 (5.6%)	0.463
Meropenem+Cefoperazone/Sulbactam	3 (1.8%)	0 (0.0%)	3 (2.4%)	0.337
Others	28 (17.1%)	8 (21.1%)	20 (15.9%)	0.457
Combination three antibiotics	14 (8.5%)	4 (10.5%)	10 (7.9%)	0.617
Meropenem+Vancomycin+Ceftazidime	6 (3.7%)	3 (7.9%)	3 (2.4%)	0.113
Meropenem+Ceftazidime+Tigecycline	5 (3.0%)	1 (2.6%)	4 (2.4%)	0.864
Others	3 (1.8%)	0 (0.0%)	3 (2.4%)	0.337