Table 2.

Top 20 Biological Functions (Lowest Adjusted P Value) of Proteins with Differing Expression Levels between Capillary and Schirmer Strip Samples

		Higher Expression in
		Capillary		Schirmer Strip
Categories	Diseases or Functions Annotation	P (Adjusted)	No. of Proteins	P (Adjusted)	No. of Proteins
Antimicrobial response	Antibacterial response	3.68E-06	12
Cell death and survival	Necrosis			2.91E-16	106
	Apoptosis			4.06E-13	99
	Cell survival			2.53E-11	66
	Cell viability			1.98E-10	62
Cell-to-cell signaling and interaction	Adhesion of blood cells	7.16E-06	19
Cellular function and maintenance	Receptor-mediated endocytosis	6.58E-31	36
	Endocytosis	1.42E-23	45
Cellular movement	Migration of cells	6.67E-19	78	8.17E-12	82
	Cell movement	8.31E-18	81	8.41E-20	104
	Leukocyte migration	2.87E-28	64
Free radical scavenging	Metabolism of reactive oxygen species			2.69E-13	38
	Synthesis of reactive oxygen species			9.09E-12	35
Humoral immune response	Complement activation	1.51E-44	36
	Classical complement pathway	4.89E-40	30
Inflammatory response	Degranulation of neutrophils	2.72E-14	29	7.74E-37	56
	Degranulation of cells	1.41E-13	35	2.99E-41	72
	Degranulation			8.23E-42	73
	Degranulation of phagocytes			3.08E-33	58
	Degranulation of blood platelets			1.22E-14	20
	Inflammation of organ			2.95E-14	69
	Inflammation of body cavity			1.01E-09	45
Nucleic acid metabolism	Metabolism of nucleic acid component or derivative			6.68E-10	32
Posttranslational modification/protein degradation/protein synthesis	Metabolism of protein	1.1E-10	46	8.66E-18	68
	Catabolism of protein	7.47E-07	27	5.52E-10	37
	Cross-linkage of peptide	4.64E-06	6
	Proteolysis	5.31E-06	16
	Metabolism of cellular protein	6.26E-06	13
	Cleavage of protein fragment	2.55E-05	14
	Folding of protein			2.95E-14	19
	Synthesis of protein			1.50E-10	35
Tissue development/cell morphology	Keratinization	3.81E-11	18
	Keratinization of epidermis	1.1E-09	15
	Formation of skin	4.36E-06	21