Table 2.
Features of histological scoring and features of C3GN and C3 Control biopsy samples
| Histology features | C3GN patients (n = 10) |
C3 Control (n = 21) |
p value |
|---|---|---|---|
| Light Microscopy patterns | |||
| Normal (%) | 10 (n = 1) | 14 (n = 3) | 1 |
| MPGN (%) | 60 (n = 6) | 5 (n = 1) | < 0.01 |
| Mesangial proliferation (%) | 30 (n = 3) | 57 (n = 12) | 0.3 |
| Endocapillary proliferation (%) | 40 (n = 4) | 14 (n = 3) | 0.2 |
| Leucocyte infiltration (%) | 30 (n = 3) | 19 (n = 4) | 0.7 |
| Cellular or fibrocellular crescents (%) | 30 (n = 3) | 38 (n = 7) | 1 |
| Immunofluorescence | |||
| C3 alone (%) | 80 (n = 8) | 24 (n = 5) | 0.05 |
| C3 dominant (with trace or 1+ Ig) (%) | 20 (n = 2) | 38 (n = 7) | 0.4 |
| C3 dominant (with trace > 2+ Ig) (%) | 0 | 38 (n = 7) | 0.03 |
| Electron microscopy findings | |||
| No deposits (%) | 0 | 38 (n = 7) | 0.02 |
| Any deposits (%) | 100 (n = 10) | 62 (n = 13) | 0.5 |
| Mesangial (%) | 40 (n = 4) | 19 (n = 4) | 0.7 |
| Subendothelial (%) | 20 (n = 2) | 24 (n = 5) | 0.6 |
| Subepithelial (%) | 10 (n = 1) | 5 (n = 1) | 1.00 |
| All 3 locations (%) | 30 (n = 3) | 14 (n = 3) | 0.4 |
| Deposit features | |||
| Amorphous (%) | 50 (n = 5) | 5 (n = 1) | 0.007 |
| Dense (%) | 10 (n = 1) | 14 (n = 3) | 0.6 |
| Patchy (%) | 30 (n = 3) | 52 (n = 11) | 0.2 |
| Subendothelial humps (%) | 10 (n = 1) | 30 (n = 6) | 0.4 |