Table 2.
Released cytokines and changes in liver mRNA/protein expression and activity of main cytochromes (CYP1A, 3A, 2B, 2C and 2D) and UGT1A in several experimental animal models of infection and chronic inflammationa.
| Inflammatory stimulus | Animal species | Released cytokines | CYP | 1A | 3A | 2B | 2C9b | 2C19b | 2D | UGT1A | References |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lipopolysaccharide | 129S1/svImJ mice | IL-1β, IL-6, TNF-α | mRNAProteinActivity | Decreased - - | Decreased Decreased - | Decreased Decreased - | Decreased Unchanged - | - | - | Decreased Decreased - | (Richardson & Morgan, 2005; Richardson, Sherman et al, 2006) |
| Lipopolysaccharide (> 5 mg/kg bw) | DBA-2 mice | TNF-α, IL-1β, IFNγ, IL-6, IL-17, IL-2, Il-10, IL-4 | mRNAProteinActivity | - - Decreased | - | - - Decreased | - | - | - | - | (De-Oliveira et al., 2015; Moriya et al., 2012) |
| Citrobacter rodentium | C3H/HeOuJ mice | IL-1β, IL-6, TNF-α | mRNAProteinActivity | Unchanged - - | Decreased - Decreased | - | Decreased Decreased | - | - | Decreased Decreased - | (Richarson, Sherman et al, 2006; Richardson, Sherman, Kalman, & Morgan, 2006) |
| Citrobacter rodentium | C57BL/6 mice | IL-6, TNF-α, IL-1β | mRNAProteinActivity | Decreased - - | Decreased Unchanged - | Unchanged Decreased - | Unchanged Decreased - | - | Increased Decreased - | - | (Kinloch et al., 2011) |
| Citrobacter rodentium | C57BL/6 mice | TNF-α, IL-6, IFN-γ, IL-10, IL-1β | mRNAProteinActivity | Increased - | Decreased Unchanged - | Decreased - - | Unchanged - | - | Unchanged | - | (Nyagode et al., 2014) |
| Citrobacter rodentium | C57BL/6 mice | IL-2, IL-6, IL-13, IFNβ, MCP-1, increasedIL-1β, IL-4, IL-5, IL-9,IL-10 unaffected | mRNAProteinActivity | Decreased - - | Decreased Decreased - | Decreased Decreased - | Decreased Decreased - | - | Increased Increased - | - | (Chaluvadi, Kinloch, et al., 2009) |
| Schistozomia mansoni (45 days post infection) | Swiss Webster mice | IL-4, IL-5, IL-13, IL-10, TGFβ1, TGFβ2, IL-1β, IL-6, IFNγ, TNF-α | mRNAProteinActivity | Decreased Decreased - | Decreased Decreased - | Decreased Decreased | Decreased Decreased - | Decreased Decreased - | Decreased Decreased - | Decreased - - | (Mimche et al., 2014) |
| Plasmodium chabaudi chabaudi | C57BL/6 mice | IL-1β, TNF-α, IFNγ, IL-6(mRNA) | mRNAProteinActivity | Decreased - Decreased | Decreased Decreased Decreased | - - Decreased | Decreased Decreased Decreased | Decreased Decreased Decreased | Unchanged Decreased Decreased | Decreased - - | (Mimche et al., 2019) |
| Ovalbumin - multiple challenges | ICR mice | - | mRNAProteinActivity | - Unchanged Decreased | - Unchanged Decreased | - | - Unchanged Decreased | - | - Unchanged Decreased | - | (Tanino et al., 2019) |
| Human T-cell leukemia virus type I transgenic mice (rheumatoid arthritis model) | BALB/c mice | IL-1β, IL-6TNF-α unaffected | mRNAProteinActivity | - | Decreased Decreased Decreased | - | Unchanged - - | - | - | - | (Ashino et al., 2007) |
| Collagen antibody induced arthritis | BALB/c mice | IL-1β, IL-6, SAAIL-2, TNF-α unaffected | mRNAProteinActivity | Decreased - Decreased | Decreased - Decreased | Decreased - Decreased | Decreased - Decreased | - | +/- - Unchanged | Decreased - - | (Dickmann et al., 2012) |
| Mycobacterium tuberculosis (adjuvant arthritis model) | Lewis rats | TNF-α, IL-1β, IL-1α, IL-6 | mRNAProteinActivity | - | Decreased Decreased Decreased | Decreased Decreased Decreased | - | - | - | - | (Sanada et al., 2011) |
| Trinitrobenzene sulfonic acid-induced colitis (model of inflammatory bowel disease) | Wistar rats | IL-6 | mRNAProteinActivity | - Unchanged Decreased | - Decreased Decreased | - | - Decreased Decreased | - | - | (Masubuchi et al., 2008) | |
| Citrobacter Rodentium (model of inflammatory bowel disease) | C57BL/6 mice | IL-2, IL-6, TNF-α, KC, IFNγ, MIP1α, MCP-1, RANTES | mRNAProteinActivity | Decreased Decreased - | Decreased Decreased - | Decreased Decreased - | Decreased Decreased - | - | Increased Increased - | - | (Chaluvadi, Nyagode, et al., 2009) |
| Mycobacterium butyricum (adjuvant arthritis model) | Sprague-Dawley rats | TNF-α | mRNAProteinActivity | - Decreased Decreased | - Decreased Decreased | - | - | - | - | - | (Ling & Jamali, 2005) |
| diabetes | Zucker fatty rat | - | mRNAProteinActivity | Unchanged Unchanged Unchanged | Decreased Decreased Decreased | Decreased Decreased Decreased | Unchanged Unchanged Unchanged | Decreased Decreased Decreased | - | - | (Yao et al., 2019) |
| Streptozotocin-induced diabetes mellitus | Sprague-Dawley rats | - | mRNAProteinActivity | - Increased - | - Increased Increased | - Increased - | - | - Decreased - | - Increased - | - | (Gwak et al., 2020) |
| Engelbreth-Holm-Swarm sarcoma (model of extra-hepatic cancer) | C57BL/6 mice | IL-6 | mRNAProteinActivity | - | Decreased - Decreased | - | - | - | - | - | (Kacevska et al., 2013) |
| High fat diet | Sprague-Dawley rats | - | mRNAProteinActivity | Decreased Decreased Decreased | +/- +/- Unchanged | Decreased - Decreased | - | Decreased Decreased Decreased | Unchanged - Unchanged | Decreased - Decreased | (Zhang et al., 2019) |
IFNβ: beta interferon, IFNγ: gamma interferon, IL: interleukin, MIP-1α: macrophage inflammatory protein 1α, MCP-1: monocyte chemoattractant protein-1, KC: chemokine CXCL1, mRNA: messenger ribonucleic acid, RANTES: chemokine CCL5, SAA, serum amyloid A, TNFα: tumor necrosis factor alpha, -: not determined, +/- according to the considered isoenzymes.
a
List of publications indicated in this table is not exhaustive. For example, because studies investigating the impact of diabetes on various animal models were recently reviewed (Wu & Lin, 2019), this table does not include the works discussed in that review, except those which were published after its publication.
b
According to Yao et al. (2019), human CYP2C9 and CYP2C19 corresponds to CYP2C11 and CYP2C22 in rats.