Table 2.
Summary of studies evaluating pectin, guar gum and glucomannan in dumping syndrome
Study | n | Treatment | Result |
---|---|---|---|
Jenkins et al.104 | 9 | Pectin 14.5 g, single administration prior to OGTT | Improved symptoms and glycaemia levels (normalized in 46%) during OGTT |
Jenkins et al.105 | 11 | Pectin 14.5 g, single administration prior to OGTT | Improved postprandial levels of glucose, insulin and enteroglucagon; reduced hypoglycaemia |
Leeds et al.153 | 11 | Pectin 15 g, single administration prior to OGTT | Improved vasomotor symptoms and glycaemia levels, lower insulin levels and slower gastric emptying during OGTT |
Lawaetz et al.44 | 4 | Pectin 15 g, single administration prior to OGTT | Reduced vasomotor symptoms, lower levels of insulin, glucagon, neurotensin and gastric inhibitory polypeptide, and slower initial gastric emptying during OGTT |
Andersen et al.100 | 5 | Pectin 5 g, single administration prior to muffin meal | No effect on symptoms or gastric emptying rate |
Harju and Larmi101 | 11 | Guar gum 5 g with meals | Improvement of symptoms |
Harju et al.102 | 11 | Guar gum 5 g with meals | Slowing of gastric emptying |
Harju and Makela103 | 11 | Guar gum 5 g with a glucose challenge meal | Improvement of symptoms and hyperglycaemia after a glucose challenge meal |
Kneepkens et al.106 | 8 children | Glucomannan 1.3 g, single administration prior to OGTT | Improvement of glucose tolerance, no effect on glucose absorption; however, no consistent effect on symptoms was seen |
OGTT, modified oral glucose tolerance test.