Table 2.
Methylation status and frequency of top 10 differentially methylated genes in delayed cerebral ischemia (DCI) and non-DCI patients following subarachnoid hemorrhage.
| CpG site ID | Methylation in the DCI (vs non-DCI) | p-value | Q-value | Difference in beta value | Chromosome | Position | Distance to transcription start site (bp) | Gene name | Gene description |
|---|---|---|---|---|---|---|---|---|---|
| cg00441765 | Hyper | 8.55E−11 | 1.90E−05 | 0.0485 | chr19 | 7,194,996 | 99,317 | INSR | Insulin receptor |
| cg11464053 | Hyper | 1.01E−10 | 1.90E−05 | 0.0440 | chr11 | 619,080 | 5,986 | CDHR5 | Cadherin related family member 5 |
| cg08969578 | Hypo | 3.16E−10 | 2.54E−05 | − 0.1450 | chr3 | 121,717,880 | 23,247 | ILDR1 | Immunoglobulin like domain containing receptor 1 |
| cg15090337 | Hypo | 3.32E−10 | 2.54E−05 | − 0.0451 | chr20 | 31,165,773 | 7,102 | NOL4L | Nucleolar protein 4 like |
| cg02180699 | Hypo | 4.02E−10 | 2.54E−05 | − 0.0858 | chr8 | 102,219,149 | − 857 | ZNF706 | Zinc finger protein 706 |
| cg26306080 | Hypo | 4.01E−10 | 2.54E−05 | − 0.0337 | chr19 | 19,550,743 | 4,871 | MIR640 | MicroRNA 640 |
| cg26826512 | Hyper | 5.05E−10 | 2.73E−05 | 0.0512 | chr3 | 185,046,528 | − 34,308 | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13 |
| cg09217327 | Hypo | 9.73E−10 | 3.68E−05 | − 0.0126 | chr22 | 30,234,641 | − 348 | ASCC2 | Activating signal cointegrator 1 complex subunit 2 |
| cg23222472 | Hypo | 1.06E−09 | 3.68E−05 | − 0.1144 | chr7 | 112,135,961 | 14,895 | LSMEM1 | Leucine rich single-pass membrane protein 1 |
| cg19751670 | Hyper | 8.56E−10 | 3.68E−05 | 0.2183 | chr8 | 23,088,262 | 5,528 | LOC389641 | Uncharacterized LOC389641 |