Table 3.
Anthropometric and metabolic characteristics of rs694539 NNMT genotypes (recessive model).
| GG/GA n = 194 |
AA n = 6 |
t/z | P | |
|---|---|---|---|---|
| Weight (kg) | 77 ± 18 | 59 ± 9 | 2.24 | 0.026 |
| BMI (kg/m2) | 28.7 ± 7 | 22.4 ± 1.8 | 2.20 | 0.028 |
| Glucose (mg/dL) | 89 ± 12 | 82 ± 11 | 1.26 | NS |
| Total cholesterol (mg/dL) | 180 ± 35 | 169 ± 32 | 0.73 | NS |
| HDL-c (mg/dL) | 51 ± 15 | 52 ± 12 | 0.11 | NS |
| LDL-c (mg/dL) | 101 ± 36 | 98 ± 33 | 1.08 | NS |
| Triglycerides (mg/dL) | 109 (77–154) | 80 (63–102) | 1.22 | NS |
| Insulin (µIU/mL) | 10.3 (7.8–15.2) | 8.4 (6.4–12) | 1.28 | NS |
| Acylated ghrelin (pg/mL) | 105 (61–144) | 115 (59–121) | 0.001 | NS |
| Leptin (ng/mL) | 30 (14–50) | 24 (10–40) | 0.58 | NS |
| HOMA-IR | 2.2 (1.6–3.3) | 1.7 (1.0–2.5) | 1.38 | NS |
| MNA-1 (ng/mL) | 11 (7.9 – 18.9) | 5.95 (3.0–12.6) | 1.62 | NS |
| REE (Kcal/day) | 1637 ± 341 | 1,329 ± 312 | 2.18 | 0.03 |
The values are expressed as the means ± SD or medians and interquartile range. The differences between lean and obese subjects were evaluated using Student’s t-test or Mann–Whitney U test. BMI = body Mass Index, HDL = high-density lipoproteins, LDL = low-density lipoproteins, HOMA-IR = homeostasis model assessment insulin resistance, MNA-1 = N1-methylnicotinamide, REE = resting energy expenditure.