Table 4.
Anthropometric and metabolic characteristics of rs1941404 NNMT genotypes (recessive model).
| TT/CT n = 171 |
CC n = 25 |
t/z | P | |
|---|---|---|---|---|
| Weight (kg) | 75 ± 19 | 79 ± 18 | -0.91 | NS |
| BMI (kg/m2) | 28 ± 7 | 30.8 ± 7 | -1.85 | 0.06 |
| Glucose (mg/dL) | 88 ± 11 | 89 ± 14 | -0.24 | NS |
| Total cholesterol (mg/dL) | 179 ± 34 | 179 ± 39 | -0.01 | NS |
| HDL-c (mg/dL) | 52 ± 15 | 50 ± 14 | 0.66 | NS |
| LDL-c (mg/dL) | 102 ± 30 | 97 ± 46 | 0.69 | NS |
| Triglycerides (mg/dL) | 109 (76–156) | 97 (78–128) | 1.01 | NS |
| Insulin (µIU/ml) | 10.3 (7.3 – 15) | 10.3 (7.5–13) | 0.015 | NS |
| Acylated ghrelin (pg/mL) | 107 (61–147) | 90 (61–136) | -0.55 | NS |
| Leptin (ng/mL) | 25.6 (13–48) | 40.9 (15–63) | -1.9 | 0.05 |
| HOMA-IR | 2.2 (1.6–3.2) | 2.3 (1.7–3.3) | 0.23 | NS |
| MNA-1 (ng/mL) | 9.4 (7.8–14.9) | 13.3 (7.8–20.8) | -1.18 | NS |
| REE (Kcal/day) | 1628 ± 351 | 1596 ± 298 | 0.43 | NS |
The values are expressed as the means ± SD or medians and interquartile range. The differences between lean and obese subjects were evaluated using Student’s t-test or Mann–Whitney U test. BMI = body Mass Index, HDL = high-density lipoproteins, LDL = low-density lipoproteins, HOMA-IR = homeostasis model assessment insulin resistance, MNA-1 = N1-methylnicotinamide, REE = resting energy expenditure.