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. 2020 Jul 10;10:11425. doi: 10.1038/s41598-020-68205-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of HFn-DOX and TZ mitochondrial cardiotoxicity. Hearts from treated mice were fixed with glutaraldehyde and embedded in epoxy-resin. At least 10 TEM images of ultrathin heart sections have been acquired at 4,200 and 11,500 magnifications for each experimental group. Quantification of mitochondria area and area occupied by cristae were performed on at least 10 images/group, measuring at least 100 mitochondria/sample, while count of mitochondria number were performed on at least 10 images/group. Values represent the mean mitochondria number ± s.e. (A), the mean mitochondrial area ± s.e. (B) and the percentage of mitochondrial area occupied by cristae ± s.e. (C). Statistical significance vs. Placebo ****P < 0.0001; vs TZ ^####P < 0.0001 (Kruskal-Wallis test). (D) Representative images of mitochondria from hearts excised at day 24 (n = 3/group) from treated mice acquired at 11,500 magnifications evidenced mitochondria morphological alterations.