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. 2020 Jul 10;11(7):522. doi: 10.1038/s41419-020-2729-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Volcano plot illustrated 294 differentially expressed genes between the si-LINC01446-treated and control SGC7901 cells (FC ≥ 2, P < 0.05). b Heatmap for the altered genes between the si-LINC01446-treated and control SGC7901 cells. c, d The mRNA expressions of altered genes were selectively verified after LINC01446 knockdown. e, f The mRNA expressions of altered genes were selectively verified using qRT-PCR after LSD1 knockdown. g The RASD1 expression in SGC7901 and BGC823 cells was analyzed after LINC01446 interference. h, i The enrichments of LSD1 and demethylated H3K4me2 at the promoter region of RASD1 were assessed using ChIP after LINC01446 knockdown. Data were shown as mean ± SD, n = 3. Student’s t test. *P < 0.05. n.s. not significant.