Table 2.

Univariate and multivariate Cox regression analysis of LINC01446 and survival in patients with GC.

Variables	Univariate analysis			Multivariate analysis
	P value	HR	95% CI	P value	HR	95% CI
OS
Age (≤60, >60)	0.995	1.000	0.979–1.022	0.960	0.999	0.977–1.022
Gender (male, female)	0.125	0.636	0.357–1.134	0.441	0.784	0.421–1.457
Lauren classification	0.154	0.720	0.459–1.131	0.021	0.576	0.361–0.919
TNM stage (I/II, III/IV)	<0.001	2.610	1.843–3.696	<0.001	2.547	1.775–3.655
Tumor invasion depth (T1/T2, T3/T4)	0.064	1.283	0.985–1.671	0.440	0.895	0.677–1.185
Lymph node metastasis (N0, N1)	0.003	1.418	1.125–1.786	0.760	0.952	0.693–1.308
Distant metastasis (yes, no)	<0.001	4.400	2.432–7.959	0.991	1.007	0.297–3.413
LINC01446 expression	<0.001	5.730	3.106–10.568	<0.001	4.446	2.409–8.206
DFS
Age (≤60, >60)	0.993	1.000	0.979–1.022	0.946	1.001	0.978–1.024
Gender (male, female)	0.122	0.626	0.351–1.116	0.371	0.752	0.403–1.403
Lauren classification	0.153	0.721	0.460–1.028	0.020	0.576	0.362–0.917
TNM stage (I/II, III/IV)	<0.001	2.594	1.834–3.670	<0.001	2.566	1.786–3.687
Tumor invasion depth (T1/T2, T3/T4)	0.069	1.275	0.981–1.657	0.371	0.881	0.667–1.163
Lymph node metastasis (N0, N1)	0.002	1.433	1.137–1.806	0.983	0.996	0.698–1.421
Distant metastasis (yes, no)	<0.001	4.346	2.405–7.851	0.845	1.113	0.379–3.267
LINC01446 expression	<0.001	6.126	3.324–11.289	<0.001	4.928	2.671–9.090

HR > 1, risk for death increased; HR < 1, risk for death reduced. Significant P values are shown in bold font.

OS overall survival, DFS disease-free survival, TNM tumor node metastasis, HR hazard ratio, CI confidence interval.