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. 2020 Jul 10;10:11448. doi: 10.1038/s41598-020-68224-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Herb-compound-target-pathway network. The red squares represent the YZHG; the orange triangles represent the four drugs in the YZHG; the yellow circles represent the ingredients in each drug; the green circles represent the targets corresponding to the ingredients; and the purple hexagons represent the pathways enriched with the targets. (b) Illustration of the crucial biological processes involving putative targets and known therapeutic targets of YZHG: signal transducer and activator of transcription 3, cyclin-dependent kinase 2, transcription factor AP1, cAMP-response element-binding protein, signal transducer and activator of transcription 5, and cellular tumor antigen p53.