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. 2020 Jul 7;472(7):831–844. doi: 10.1007/s00424-020-02429-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Cladogram representation of the Cav channel family including the gene names and the corresponding Cav subunits. HVA stands for high-voltage activated channels (L-, P/Q-, N-, and R-types) and LVA stands for low-voltage activated channels (T-type). The channelopathies column refers to the overall so-called Ca²⁺ channelopathies, with the detailed properties of the Cav3 channelopathies presented and discussed in the text. The diseases caused by mutations in the S6 segments of the corresponding Cav channels are indicated (#)