Table 1.
Cohort overview and functional visual outcomes
| SCA-PRKCG | HC | p | |
|---|---|---|---|
| Total | 12 | 14 | |
| Sex | |||
| Male | 6 | 8 | 0.716 (Chi2) |
| Female | 6 | 6 | |
| Age/years | |||
| Mean ± SD | 51.75 ± 13.6 | 50.7 ± 11.1 | 0.820 (MWU) |
| Range | 29–70 | 30–65 | |
| Disease duration | |||
| Years, mean ± SD | 20.7 ± 13.7 | ||
| Range | 0–44 | ||
| SARA score | |||
| Mean ± SD | 11.4 ± 3.6 | ||
| Range | 6.5–20.5 | ||
| Visual acuity | |||
| Logmar score monocular ± SD | 0.04 ± 0.14 | − 0.02 ± 0.10 | 0.137 (GEE) |
| Logmar score binocular ± SD | − 0.03 ± 0.12 | − 0.13 ± 0.82 | 0.036 (MWU) |
| FACT AULCSF binocular ± SD | 1.92 ± 0.15 | 2.11 ± 0.06 | p < 0.001 (MWU) |
Values for both groups are mean ± standard deviation. Significant p values are printed in italics
AULCSF area under the log contrast sensitivity function, HC healthy control, FACT Functional Acuity Contrast Test, GEE generalized estimation equation models, logMAR logarithm of the minimal angle of resolution, MWU Man-Whitney U test, SARA scale for the assessment and rating of ataxia, SCA-PRKCG spinocerebellar ataxia type 14, SD standard deviation