Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 24;472(7):755–773. doi: 10.1007/s00424-020-02418-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Scheme of the position of de novo germline and de novo somatic APA/APCC variants within the Cav1.3 α1-subunit. The α1-subunit consists of four homologous repeats (I–IV), each comprising six transmembrane segments (S1–S6). From each repeat, S1–S4 form the voltage sensors (S4 contains the positive gating charges) and S5–S6 with their connecting loop build the ion conducting pore. The S4–S5 loop links the voltage-sensor movements to the pore opening. Color code: germline (orange), somatic (blue)