Table 3.

Population kinetic parameters in the final model for infusion experiments in the extended analysis of 91 volunteers

	Covariate	Best estimate	2.5% CI	97.5% CI	CV%	− 2(LL)
Fixed parameters
Vc (L)	-	3.54	3.14	3.93	5.7
k12 (10−3 min−1)	-	73.6	58.7	88.5	10.2
k21 (10−3 min−1)	-	59.6	49.9	69.3	8.3
k10 (10−3 min−1)	-	20.3	17.4	23.1	7.1	− 4298
kb (10−3 min−1)	-	11.2	8.1	14.3	14.2	− 4399
Covariate effect
Vc	Gender	− 0.33	− 0.48	− 0.19	− 22.2	− 4414
Vc	Infusion rate (mL/min)	0.43	0.24	0.62	22.9	− 4432

Infusion rate is a power model with a mean infusion rate of 58.0 mL/min. Gender is an exponential model where male = 0 and female = 1. The latter becomes (e ^− 0.33). The full block model did not converge to yield 95% CI

CI confidence interval, CV between-subject coefficient of variation, LL log likelihood