Table 2.
Declines in 3MS scores for a 5-year increase in age at specific plasma 25(OH)D concentrations
| Model 1a | Model 2a | Model 3a | |
|---|---|---|---|
| Beta (95% CI) | Beta (95% CI) | Beta (95% CI) | |
| 25(OH)D | |||
| Global | |||
| At 23.4 nmol/L | − 2.20 (− 2.94; − 1.45) | − 2.17 (− 2.91; − 1.42) | − 2.19 (− 2.94; − 1.44) |
| At 42.4 nmol/L | − 2.11 (− 2.68; − 1.53) | − 2.05 (− 2.63; − 1.46) | − 2.08 (− 2.67; − 1.49) |
| At 69.4 nmol/L | − 2.03 (− 2.80; − 1.26) | − 1.95 (− 2.73; − 1.17) | − 1.98 (− 2.76; − 1.20) |
| p value for 25(OH)D | 0.7926 | 0.6879 | 0.6938 |
| p value for 25(OH)D by age interaction | 0.7412 | 0.6682 | 0.6731 |
| Men | |||
| At 23.4 nmol/L | − 1.52 (− 2.61; − 0.43) | − 1.47 (− 2.56; − 0.38) | − 1.48 (− 2.57; − 0.38) |
| At 42.4 nmol/L | − 1.43 (− 2.35; − 0.51) | − 1.35 (− 2.27; − 0.43) | − 1.36 (− 2.29; − 0.44) |
| At 69.4 nmol/L | − 1.35 (− 2.35; − 0.35) | − 1.25 (− 2.26; − 0.25) | − 1.26 (− 2.27; − 0.26) |
| Women | |||
| At 23.4 nmol/L | − 2.87 (− 3.64; − 2.11) | − 2.86 (− 3.64; − 2.09) | − 2.91 (− 3.69; − 2.13) |
| At 42.4 nmol/L | − 2.78 (− 3.48; − 2.09) | − 2.75 (− 3.45; − 2.04) | − 2.79 (− 3.51; − 2.08) |
| At 69.4 nmol/L | − 2.71 (− 3.63; − 1.79) | − 2.65 (− 3.58; − 1.72) | − 2.70 (− 3.63; − 1.76) |
25(OH)D, 25-hydroxyvitamin D; 3MS, Modified Mini-Mental State examination; ApoE4, allele e4 on apolipoprotein E gene; BMI, body mass index; CI, confidence interval
These specific 25(OH)D concentrations correspond to the median points of each tertile group of the distribution of the study sample
aBetas adjusted for age, education, sex and phase, with interaction term between 25(OH)D and age, and between sex and age in model 1; additionally adjusted for ApoE4, BMI, alcohol drinking, smoking and institutionalization in model 2; additionally adjusted for depression, hypertension, diabetes, and history of stroke or myocardial infarction in model 3