Table 3.
Hazard ratios (HR) for all-cause dementia and Alzheimer’s disease associated with 25(OH)D status (n = 661)
| Dementia | Alzheimer’s disease | |||
|---|---|---|---|---|
| Events (n, %) | HR (95% CI)a | Events (n, %) | HR (95% CI)a | |
| 25(OH)D (per 50% increase) | ||||
| Global | 141 (21.3) | 100 (15.1) | ||
| Model 1 | 1.04 (0.92–1.17) | 1.12 (0.97–1.30) | ||
| Model 2 | 1.09 (0.97–1.23) | 1.15 (0.99–1.33) | ||
| Model 3 | 1.11 (0.98–1.26) | 1.18 (1.02–1.37) | ||
| Men | 47 (17.6) | 34 (12.7) | ||
| Model 1 | 0.92 (0.75–1.14) | 0.87 (0.69–1.11) | ||
| Model 2 | 0.95 (0.77–1.18) | 0.89 (0.70–1.14) | ||
| Model 3 | 0.98 (0.79–1.21) | 0.93 (0.72–1.19) | ||
| Women | 94 (23.9) | 66 (16.8) | ||
| Model 1 | 1.10 (0.95–1.27) | 1.25 (1.05–1.50) | ||
| Model 2 | 1.16 (1.01–1.35) | 1.28 (1.08–1.53) | ||
| Model 3 | 1.17 (1.01–1.36) | 1.31 (1.10–1.56) | ||
25(OH)D, 25-hydroxyvitamin D; 3MS, Modified Mini-Mental State examination; ApoE4, allele e4 on apolipoprotein E gene; BMI, body mass index; CI, confidence interval; HR, hazard ratio; CIND, cognitive impairment no dementia
aHRs and 95% CIs adjusted for age (as time scale), sex, education and phase in model 1; additionally adjusted for ApoE4, BMI, alcohol drinking, smoking, CIND and institutionalization in model 2; additionally adjusted for depression, hypertension, diabetes, and history of stroke and myocardial infarction in model 3. An interaction term between 25(OH)D and sex was introduced in global models to obtain HRs separately for men and women
Italicized values are statistically significant