Table 1.

Comparison of mean Adrenaline, Glucagon, Cortisol and Insulin in methadone treated and control group both female and male Wistar rats

Variables	Groups				p value
	Female rats (n = 10)		Male rats (n = 10)
	Methadone	Control	Methadone	Control
Adrenaline (ng/ml(	30.2 ± 1.26	29.84 ± 1.8	25.76 ± 2.15	33.55 ± 2.58	0.03*
Glucagon (ng/ml)	100.19 ± 5.06	112.03 ± 7.65	97.51 ± 11.57	126.51 ± 8.39	0.14
Cortisol (ng/ml(	85.42 ± 4.14	75.95 ± 3.52	69.97 ± 5.09	86.26 ± 4.41	0.02*
Insulin (mIU/L(	5.41 ± 0.16	5.71 ± 0.36	4.84 ± 0.35	5.85 ± 0.44	0.24

Values are expressed as mean ± SD (One-way ANOVA and Bonferroni post hoc tests)

*p < 0.05 is significant