Table 2.

Comparison of mean HDL, LDL, TG and total cholesterol in methadone treated and control group both female and male Wistar rats

Variables	Groups				p value
	Female rats (n = 10)		Male rats (n = 10)
	Methadone	Control	Methadone	Control
HDL (mg/dL)	49.50 ± 2.47	55.90 ± 2.29	43.62 ± 0.94	50.20 ± 1.25	≤ 0.001*
LDL (mg/dL)	17.30 ± 0.21	16.50 ± 0.17	18.75 ± 0.29	18.10 ± 0.23	≤ 0.001*
TG (mg/dL)	32.00 ± 2.51	32.03 ± 2.82	32.00 ± 1.38	40.04 ± 2.05	0.01*
Total cholesterol (mg/dL)	66.70 ± 3.25	66.10 ± 3.11	66.75 ± 2.71	59.10 ± 2.05	0.8

Values are expressed as mean ± SD (One-way ANOVA and Bonferroni post hoc tests)

HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglyceride

*p < 0.05 is significant