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. 2020 Jul 10;11:3464. doi: 10.1038/s41467-020-17271-9

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Ribbon representation of the structural assembly of the DOCK2–ELMO1 protomer. DOCK2, ELMO1 and RAC1 are highlighted in cyan, yellow-orange and red backgrounds, respectively. Insert shows the major stable interface between DOCK2 and ELMO1 involving the six α-helical bundle. b Ribbon representation of DOCK2. Domains are labelled and colour-coded according to the domain scheme in Fig. 1a. c Close-up view of the dimer interface formed by lobe A of the DHR2 domains of each DOCK2 monomer (shown in purple and grey-blue). Lobe A, B and C of the DOCK2 DHR2 domains are labelled. d DOCK2^ARM is rainbow-coloured from blue (N-terminus) to red (C-terminus). e Close-up view of the interaction interface between DOCK2^DHR2, ELMO1^PH domain and RAC1. The switch 1 and switch 2 loops of RAC1 are coloured in yellow and green, respectively. f Ribbon representation of ELMO1 colour-coded according to Fig. 1a.