Table 2.
Multiple Logistic Regression Model Predicting 2-Year Weight Gain ≥ 10 lbs in 10,596 Veterans Treated with Direct-Acting Antivirals
| Characteristic | OR | 95% CI | Chi-square | p value |
|---|---|---|---|---|
| Demographic | ||||
| Female gender | 0.89 | 0.69–1.15 | 0.78 | 0.38 |
| Age | ||||
| < 55 | Ref | Ref | 33.61 | < 0.0001 |
| 55 to < 60 | 1.03 | 0.86–1.24 | ||
| 60 to < 65 | 0.90 | 0.75–1.08 | ||
| ≥ 65 | 0.70 | 0.57–0.85 | ||
| Race | ||||
| White | Ref | Ref | 1.48 | 0.48 |
| Black | 0.95 | 0.86–1.06 | ||
| Other | 1.07 | 0.87–1.32 | ||
| Treatment-related | ||||
| SVR achievement | 1.55 | 1.14–2.10 | 7.78 | 0.005 |
| Viral genotype | ||||
| 1 | Ref | Ref | 1.45 | 0.69 |
| 2 | 0.98 | 0.82–1.16 | ||
| 3 | 1.13 | 0.91–1.40 | ||
| 4, 5, 6, or multiple | 0.99 | 0.64–1.53 | ||
| Viral load, log-transformed (IU/mL) | 0.95 | 0.89–1.01 | 2.91 | 0.09 |
| Sofosbuvir-based drug | 0.92 | 0.80–1.05 | 1.52 | 0.22 |
| Fibrosis-4 score | ||||
| < 1.45 | Ref | Ref | 18.87 | < 0.0001 |
| 1.45 to 3.25 | 0.97 | 0.85–1.12 | ||
| > 3.25 | 1.24 | 1.06–1.44 | ||
| Cirrhosis | 1.20 | 1.08–1.34 | 11.10 | 0.0009 |
| Hepatocellular carcinoma | 0.89 | 0.70–1.14 | 0.87 | 0.35 |
| Comorbidity | ||||
| Weight class at treatment initiation | ||||
| Underweight | 0.72 | 0.34–1.53 | 24.89 | < 0.0001 |
| Normal | Ref | Ref | ||
| Overweight | 1.17 | 1.03–1.33 | ||
| Obesity class 1 | 1.25 | 1.08–1.44 | ||
| Obesity class 2/3 | 1.50 | 1.27–1.77 | ||
| GFR | ||||
| ≥ 60 | Ref | Ref | 0.01 | 0.99 |
| 30 to < 60 | 1.00 | 0.84–1.18 | ||
| < 30 | 1.03 | 0.58–1.83 | ||
| Diabetes mellitus | 1.02 | 0.92–1.13 | 0.14 | 0.71 |
| Alcohol usea | ||||
| None | 0.80 | 0.69–0.94 | 8.47 | 0.04 |
| Moderate use | Ref | Ref | ||
| Hazardous use | 0.90 | 0.63–1.29 | ||
| Alcohol use disorder | 0.88 | 0.75–1.04 | ||
| Smoking status | ||||
| Never | Ref | Ref | 1.94 | 0.38 |
| Current | 0.92 | 0.80–1.05 | ||
| Former | 0.90 | 0.78–1.05 | ||
| Illicit drug use | 0.91 | 0.81–1.01 | 2.97 | 0.08 |
| Depression/severe mental illness | 1.01 | 0.91–1.11 | 0.01 | 0.92 |
aAlcohol use categories: None, AUDIT-C score 0 without alcohol use disorder; Moderate use, as non-elevated AUDIT-C score (< 4 for men, < 3 for women), without alcohol use disorder; Hazardous use, elevated AUDIT-C score; Alcohol use disorder, diagnosis of alcohol use disorder
AUDIT-C, Alcohol Use Disorders Identifications Test-Consumption; CI, confidence interval; FIB-4, Fibrosis-4; GFR, glomerular filtration rate; OR, odds ratio; SVR, sustained virologic response