. 2020 Mar 26;36(3):203–210. doi: 10.1007/s43188-019-00013-5

Table 2.

The values of erythron, thrombon parameters and plasma protein concentration (mean ± SEM) of rats in dermal toxicity studies of M. malabathricum leaf ethanolic extract

Parameter	G1	G2	G3	G4	G5
Acute toxicity study
RBC (× 10¹²/L)	7.54 ± 0.18^a	7.38 ± 0.32^a	7.39 ± 0.45^a	7.76 ± 0.40^a	7.64 ± 0.41^a
Hb (g/L)	150.2 ± 1.68^a	156.03 ± 1.83^a	150.54 ± 1.37^a	154.1 ± 3.20^a	156.36 ± 2.06^a
PCV (L/L)	42.17 ± 0.72^a	42.18 ± 0.90^a	41.74 ± 0.79^a	39.0 ± 1.40^a	42.16 ± 1.38^a
PP (g/L)	74.54 ± 1.18^a	76.47 ± 0.61^a	74.61 ± 1.65^a	72.80 ± 1.62^a	74.73 ± 0.81^a
MCV (fL)	63.14 ± 1.49^a	61.15 ± 0.96^a	62.70 ± 0.80^a	62.87 ± 1.05^a	63.54 ± 0.61^a
MCHC (g/L)	302.26 ± 10.14^a	301.07 ± 12.30^a	307.35 ± 8.34^a	341.23 ± 4.34^a	308.2 ± 5.77^a
Icterus Index (Unit)	2.00 ± 0.00^a	2.00 ± 0.00^a	2.00 ± 0.00^a	2.00 ± 0.00^a	2.00 ± 0.00^a
Platelets (10⁹/L)	1432.49 ± 61.77^a	1416.48 ± 32.38^a	1489.87 ± 68.37^a	1414.44 ± 45.07^a	1450.98 ± 17.03^a
Subacute toxicity study
RBC (× 10¹²/L)	7.51 ± 0.18^a	7.61 ± 0.32^{a a}	7.70 ± 0.42^a	7.23 ± 0.15^a	7.45 ± 0.08^a
Hb (g/L)	152.71 ± 2.00^a	151.91 ± 1.43^a	149.27 ± 2.59^a	145.29 ± 1.97^a	146.45 ± 2.31^a
PCV (L/L)	40.77 ± 0.73^a	41.57 ± 2.22^a	40.67 ± 1.45^a	43.0 ± 1.47^a	44.11 ± 0.92^a
PP (g/L)	73.12 ± 1.32^a	73.72 ± 0.71^a	72.18 ± 1.12^a	60.60 ± 15.21^a	76.29 ± 2.85^a
MCV (fL)	63.95 ± 0.39^a	63.80 ± 0.37^a	63.55 ± 0.75^a	60.76 ± 1.22^a	59.87 ± 0.79^a
MCHC (g/L)	312.36 ± 11.87^a	304.89 ± 4.08	301.20 ± 7.88^a	326.80 ± 4.63^a	325.80 ± 1.53^a
Icterus Index (Unit)	2.00 ± 0.00^a	2.00 ± 0.00^a	2.00 ± 0.00^a	2.00 ± 0.00^a	2.00 ± 0.00^a
Platelets (10⁹/L)	1432.60 ± 22.23^a	1407.54 ± 62.72^a	1481.83 ± 48.34^a	1319.17 ± 134.46^a	1478.91 ± 67.76^a

Values in the same row with similar superscripts are not significantly different at p > 0.05

G1: M. malabathricum (2.5%), G2: M. malabathricum (5%), G3: M. malabathricum (10%), G4: negative control, G5: paraffin