Table 2.
Pattern of Disease Progression in Patients with Acquired T790M Mutation
| Characteristics | All Patients (n = 87) | Patients with T790M (n = 55) | p value* |
|---|---|---|---|
| Number of progression sites, No. (%) | |||
| 1 | 46 | 31 (67.4) | 0.260 |
| 2 | 21 | 13 (61.9) | |
| 3 | 17 | 8 (47.1) | |
| 4 | 3 | 3 (100) | |
| Progression site, No. (%) | |||
| Enlarged lung primary | 14 | 10 (71.4) | 0.242 |
| New metastases | 47 | 32 (68.1) | |
| Enlarged primary and new metastases | 26 | 13 (50.0) | |
| Enlarged lung primary, No. (%) | |||
| Yes | 40 | 23 (57.5) | 0.308 |
| No | 47 | 32 (68.1) | |
| New lung metastases, No. (%) | 0.048 | ||
| Yes | 42 | 31 (73.8) | |
| No | 45 | 24 (53.3) | |
| New symptomatic brain metastases, No. (%) | 0.021 | ||
| Yes | 10 | 3 (30.0) | |
| No | 77 | 52 (67.5) | |
| New liver metastases, No. (%) | |||
| Yes | 16 | 10 (62.5) | 0.947 |
| No | 71 | 45 (63.4) | |
| New adrenal metastases, No. (%) | |||
| Yes | 2 | 2 (100.0) | 0.275 |
| No | 85 | 53 (62.4) | |
| New intrathoracic lymph node metastases, No. (%) | |||
| Yes | 21 | 10 (47.6) | 0.089 |
| No | 66 | 45 (68.2) | |
| New bone metastases, No. (%) | |||
| Yes | 18 | 13 (72.2) | 0.374 |
| No | 69 | 42 (60.9) |
Notes: *Chi-square test for categorical variables. Bold p-value was statistically significant.