Table 1.
Voxel-wise [18F]FDG PET analysis.
| Peak location for the cluster in the group comparison (at pheight < 0.005 uncorrected, KE > 200) | ||||||
|---|---|---|---|---|---|---|
| Cluster level |
Voxel level |
Structure |
||||
| pcorr | KE | T | puncorr | Intensity difference (%) | Name | |
| Controls Δ(T2-T1) < TDP-43A315T Δ(T2-T1) | 8.3*10−5 | 6720 | 5.43 | <0.001 | +8.0 ± 5.5% | Bilateral substantia nigra, amygdaloid nucleus and reticular nucleus |
| 4.71 | <0.001 | |||||
| 4.6 | <0.001 | |||||
| Controls Δ(T2-T1) > TDP-43A315T Δ(T2-T1) | 9.3*10−6 | 8941 | 7.33 | <0.001 | −15.8 ± 3.3% | Unilateral motor and somatosensory cortex |
| 4.42 | <0.001 | |||||
| 3.24 | 0.002 | |||||
| Controls Δ(T3-T1) > TDP-43A315T Δ(T3-T1) | 0.105 | 483 | 7.74 | <0.001 | −9.0 ± 5.1% | Unilateral striatum |
Summary of the SPM analysis, indicating the anatomical regions where, at a given time point, a cluster with statistically significant alterations in regional glucose metabolism was present. Peak locations for the clusters in the group comparison are given at the threshold pheight < 0.005 (uncorrected) and cluster extent > 200. Abbreviations: p(un)corr at the cluster level, the likelihood (p) of finding a voxel with this or higher T-value, p-value (un)corrected for the search volume; KE, cluster extent; T, indication of statistical significance. The age of the mice at T1-T3 scan sessions are: T1: 3.5 months, T2: 7 months, T3: 11.5 months. Intensity difference values are indicated as mean ± standard deviation.