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. 2020 Jun 25;27:102327. doi: 10.1016/j.nicl.2020.102327

Table 2.

Assessment of microstructural changes using diffusion tensor imaging.

Motor cortex
 Striatum
 Hindbrain
Controls TDP-43A315T Controls TDP-43A315T Controls TDP-43A315T
FA T3 0.25 ± 0.03 0.22 ± 0.03 0.22 ± 0.02 0.22 ± 0.02 0.35 ± 0.05 0.32 ± 0.05
T4 0.24 ± 0.03 0.20 ± 0.05 0.27 ± 0.04 0.22 ± 0.03 Ω 0.32 ± 0.04 0.30 ± 0.05
T5 0.21 ± 0.02 0.20 ± 0.03 0.20 ± 0.02 0.21 ± 0.04 0.24 ± 0.03 0.26 ± 0.03
AD(10−3 mm2/sec) T3 0.77 ± 0.03 0.76 ± 0.02 0.75 ± 0.03 0.75 ± 0.03 0.74 ± 0.09 0.72 ± 0.09
T4 0.76 ± 0.02 0.76 ± 0.04 0.77 ± 0.03 0.80 ± 0.05 0.90 ± 0.13 0.80 ± 0.09
T5 0.75 ± 0.02 0.75 ± 0.05 0.76 ± 0.02 0.77 ± 0.02 0.70 ± 0.06 0.72 ± 0.04
RD (10−3 mm2/sec) T3 0.53 ± 0.02 0.55 ± 0.03 0.54 ± 0.02 0.55 ± 0.03 0.45 ± 0.07 0.45 ± 0.08
T4 0.53 ± 0.02 0.56 ± 0.03Δ 0.52 ± 0.03 0.59 ± 0.06Θ 0.61 ± 0.13 0.51 ± 0.11
T5 0.55 ± 0.01 0.56 ± 0.02 0.56 ± 0.01 0.56 ± 0.02 0.48 ± 0.04 0.49 ± 0.02
MD (10−3 mm2/sec) T3 0.61 ± 0.02 0.62 ± 0.03 0.61 ± 0.02 0.61 ± 0.02 0.55 ± 0.08 0.54 ± 0.08
T4 0.61 ± 0.02 0.61 ± 0.03 0.60 ± 0.03 0.64 ± 0.05 0.71 ± 0.13 0.60 ± 0.01Σ
T5 0.61 ± 0.02 0.63 ± 0.020 0.63 ± 0.01 0.63 ± 0.01 0.55 ± 0.05 0.56 ± 0.02

This table depicts the region-of-interest (ROI) analysis of fractional anisotropy (FA), axial diffusion (AD), radial diffusion (RD) and mean diffusion (MD), measured in the region of the motor cortex, striatum, and hindbrain of TDP-43A315T transgenic mice and non-transgenic controls. Time points mentioned in this figure are in correspondence with following approximate age of the animals: T3: 9 months, T4: 13,5 months, T5: 16 months. Values represent mean ± standard deviation. Significant alterations in MR diffusion were obtained by using the restricted maximum likelihood estimation model. Δ p < 0.05, Ω and Σ p < 0.01, Θ p < 0.001.