Table 1.
The INSPIRE Human Translational Research cohort flow-chart
| Inclusion | Every 4-month | Yearly Visits | Every 2 years | |
|---|---|---|---|---|
| Information note | ✓ | |||
| Informed consent | ✓ | |||
| Eligibility criteria checked | ✓ | |||
| Demographic information | ✓ | |||
| Physical examinations: | ||||
| Medical history | ✓ | ✓ | ||
| Medication | ✓ | ✓ | ✓ | |
| Vaccination | ✓ | ✓ | ✓ | |
| Current diseases | ✓ | ✓ | ✓ | |
| BMI, waist & hip circumferences | ✓ | ✓ | ||
| Heart rate, blood pressure | ✓ | ✓ | ||
| Self-reported visceral pain | ✓ | ✓ | ||
| Skin elasticity (cutometer measurement) | ✓ | ✓ | ||
| Cutaneous itching/pruritus | ✓ | ✓ | ||
| Lifestyle information (physical activity, sedentarity time, smoking, alcohol consumption, solar exposure) | ✓ | ✓ | ||
| Frailty Fried phenotype | ✓ | ✓ | ||
| Functional status (ADL, IADL) | ✓ | ✓ | ||
| Cognitive status (MMSE, cognitive composite scorea) | ✓ | ✓ | ||
| Physical performance (SPPB, chair rise test (30 seconds)) | ✓ | ✓ | ||
| Depressive symptoms (PHQ-9) | ✓ | ✓ | ||
| Nutritional status (MNA, food frequency questionnaire) | ✓ | ✓ | ||
| Oral status (OHAT) | ✓ | ✓ | ||
| Participant-reported outcomes for cognition (CFI) and mobility, fatigue and social isolation (PROMIS) | ✓ | ✓ | ||
| Objective physical activity and sleep parameters (activPAL accelerometer) | ✓ | ✓ | ||
| Vision assessment (WHO simple eye chart, Amsler grid) | ✓ | ✓ | ||
| ICOPE Monitor app (IC domains) | ✓ | ✓ | ✓ | |
| Adverse events (e.g. new diagnosis, SARS COV-2 diagnosis, influenza, fracture, …) | ✓ | |||
| Other examinations: | ||||
| DXA | ✓ | ✓ | ||
| MRP | ✓ | ✓ | ||
| VO2max with blood sampling / maximal aerobic powerb | ✓ | ✓ | ||
| Isokinetic muscle strengthb | ✓ | ✓ | ||
| Patient-reported outcome for sarcopenia (SAR-Qol)b | ✓ | ✓ |
a. The cognitive composite score will be realized only in people lower than 70 years; b. Other examinations are proposed to a limited number of participants in a volunteer basis