Table 3.
Genetic model analyses of the association between PNPLA2 polymorphisms and DKD with adjustment for confounders.
| Genetic models | Genotype | DM | DKD | Without adjustment | With adjustment¶ | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |||||
| PNPLA2 rs28633403 | Additive | AA | 117 (26.7%) | 136 (35.9%) | 1# | — | 1# | — |
| AG | 224 (51.0%) | 169 (44.6%) | 0.649 (0.472-0.892) | 0.008∗ | 0.633 (0.447-0.895) | 0.010∗ | ||
| GG | 98 (22.3%) | 74 (19.5%) | 0.650 (0.440-0.960) | 0.030∗ | 0.588 (0.385-0.897) | 0.014∗ | ||
| Dominant | AA | 117 (26.7%) | 136 (35.9%) | 1# | — | 1# | — | |
| AG+GG | 322 (73.3%) | 243 (64.1%) | 0.649 (0.482-0.875) | 0.004∗ | 0.619 (0.447-0.857) | 0.004∗ | ||
| Recessive | AA+AG | 341 (77.7%) | 305 (80.5%) | 1# | — | 1# | — | |
| GG | 98 (22.3%) | 74 (19.5%) | 0.844 (0.601-1.185) | 0.328 | 0.778 (0.540-1.121) | 0.177 | ||
|
| ||||||||
| PNPLA2 rs1138714 | Additive | AA | 225 (51.3%) | 159 (42.0%) | 1# | — | 1# | — |
| AG | 180 (41.0%) | 185 (48.8%) | 1.454 (1.090-1.941) | 0.011∗ | 1.529 (1.118-2.091) | 0.008∗ | ||
| GG | 34 (7.7%) | 35 (9.2%) | 1.457 (0.871-2.435) | 0.151 | 1.545 (0.888-2.688) | 0.124 | ||
| Dominant | AA | 225 (51.3%) | 159 (42.0%) | 1# | — | 1# | ||
| AG+GG | 214 (48.7%) | 220 (58.0%) | 1.455 (1.103-1.919) | 0.008∗ | 1.531 (1.134-2.067) | 0.005∗ | ||
| Recessive | AA+AG | 405 (92.3%) | 344 (90.8%) | 1# | — | 1# | — | |
| GG | 34 (7.7%) | 35 (9.2%) | 1.212 (0.740-1.985) | 0.445 | 1.257 (0.739-2.138) | 0.399 | ||
|
| ||||||||
| PNPLA2 rs1138693 | Additive | TT | 178 (40.5%) | 157 (41.4%) | 1# | 1# | ||
| TC | 204 (46.5%) | 173 (45.6%) | 0.961 (0.716-1.292) | 0.794 | 0.915 (0.663-1.263) | 0.590 | ||
| CC | 57 (13.0%) | 49 (12.9%) | 0.975 (0.629-1.510) | 0.908 | 0.918 (0.573-1.469) | 0.720 | ||
| Dominant | TT | 178 (40.5%) | 157 (41.4%) | 1# | — | 1# | — | |
| TC+CC | 261 (59.5%) | 222 (58.6%) | 0.964 (0.729-1.275) | 0.799 | 0.916 (0.675-1.242) | 0.572 | ||
| Recessive | TT+TC | 382 (87.0%) | 330 (87.1%) | 1# | — | 1# | — | |
| CC | 57 (13.0%) | 49 (12.9%) | 0.995 (0.661-1.498) | 0.981 | 0.962 (0.621-1.491) | 0.864 | ||
Abbreviations: ORs: odds ratios; CI: confidence interval. #Reference category (odds ratio, 1.0); adjustment for age, BMI, SBP, DBP, A1C, Hcy, TC, and TG; ∗P value < 0.05 indicates statistical significance.