Table 3.

Univariable and multivariable analyses of factors associated with the overall survival.

Variables	Univariable				Multivariable				Multivariable
	p value	HR	95% CI		p value	HR	95% CI		p value	HR	95% CI
			Lower	Upper			Lower	Upper			Lower	Upper
Age ≥ 72 vs. <72 (years)	0.221	1.16	0.91	1.47
Gleason score ≥ 8 vs. ≤7	0.164	1.27	0.91	1.77
Visceral metastasis	0.766	0.94	0.62	1.42
PSA ≥ 280.4 vs. <280.4 (ng/mL)	0.001	1.48	1.16	1.88	0.252	0.84	0.62	1.13	0.605	0.93	0.69	1.24
Hb < 13.2 vs. ≥13.2 (g/dL)	<0.001	2.44	1.88	3.16	<0.001	2.16	1.63	2.88	<0.001	2.11	1.59	2.79
LDH ≥ 203 vs. <203 (IU/L)	<0.001	2.27	1.77	2.90	<0.001	2.00	1.50	2.67	<0.001	2.08	1.56	2.77
ALP ≥ 397 vs. <397 (IU/L)	<0.001	1.91	1.49	2.46	0.091	1.30	0.96	1.75	1.413	1.06	1.89
CHAARTED high volume vs. low volume	<0.001	2.21	1.66	2.93	0.003	1.73	1.21	2.50	—	—	—	—
LATITUDE high risk vs. low risk	<0.001	1.72	1.31	2.27	—	—	—	—	0.014	1.50	1.09	2.06

PSA: prostate-specific antigen; Hb: hemoglobin; LDH: lactate dehydrogenase; ALP: alkaline phosphatase.