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The changes of pyroptosis-related genes in response to CD147 treatment. (a) Real-time PCR and (b, c) western blotting were performed to analyze the changes of IL-18 and IL-1β expression. (d) Western blotting was used to detect NLRP3, ASC, caspase-1, GSDMD, and GSDME expression in the indicated group in HT-29 and Caco-2 cells. CD147 activated cell pyroptosis and contributed to IL-18 and IL-1β expression. CD147 induced pyroptosis-related gene expression in IECs.
