Table 1.

Signaling pathway enrichment analysis of DEGs in ESCC.

	Term	Count	P value
Up	hsa03030:DNA replication	13	3.51E-08
	hsa04110:cell cycle	21	8.02E-07
	hsa03050:proteasome	11	2.33E-05
	hsa03410:base excision repair	9	9.52E-05
	hsa03040:spliceosome	17	3.83E-04
	hsa03430:mismatch repair	7	4.78E-04
	hsa00240:pyrimidine metabolism	14	9.29E-04
	hsa03420:nucleotide excision repair	8	5.35E-03
	hsa05222:small-cell lung cancer	11	5.50E-03
	hsa00480:glutathione metabolism	8	8.42E-03
	hsa05230:central carbon metabolism in cancer	9	8.77E-03
	hsa04062:chemokine signaling pathway	17	1.18E-02
	hsa03013:RNA transport	16	1.29E-02
	hsa04510:focal adhesion	17	2.83E-02
	hsa00230:purine metabolism	15	3.25E-02
	hsa04115:p53 signaling pathway	8	3.39E-02
	hsa04512:ECM-receptor interaction	9	4.68E-02
	hsa04145:phagosome	13	5.00E-02
Down	hsa04810:regulation of actin cytoskeleton	11	4.23E-03
	hsa00260:glycine, serine, and threonine metabolism	5	4.86E-03
	hsa04022:cGMP-PKG signaling pathway	9	9.30E-03
	hsa00280:valine, leucine and isoleucine degradation	5	9.45E-03
	hsa00330:arginine and proline metabolism	5	1.17E-02
	hsa00072:synthesis and degradation of ketone bodies	3	1.29E-02
	hsa00410:beta-alanine metabolism	4	1.72E-02
	hsa04710:circadian rhythm	4	1.72E-02
	hsa04270:vascular smooth muscle contraction	7	1.91E-02
	hsa04924:renin secretion	5	2.68E-02
	hsa04713:circadian entrainment	6	2.68E-02
	hsa04510:focal adhesion	9	3.02E-02
	hsa00982:drug metabolism-cytochrome P450	5	3.25E-02
	hsa04610:complement and coagulation cascades	5	3.40E-02
	hsa00360:phenylalanine metabolism	3	3.59E-02
	hsa04020:calcium signaling pathway	8	4.01E-02
	hsa05146:amoebiasis	6	4.02E-02
	hsa00071:fatty acid degradation	4	4.30E-02