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. 2020 Jun 5;12(6):1474. doi: 10.3390/cancers12061474

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Three-tiered approach for FGS of SCC where (A) proposed algorithm to decide what target to use during FGS of squamous cell carcinoma of the head and neck region. (B) Illustrations depicting, based on the immunohistochemical results, where fluorescence would be expected during FGS using EGFR-, αvβ6-, or uPAR-based probes. Dark green represents more fluorescence than light green. FGS: fluorescence-guided surgery, HNSCC: head and neck squamous cell carcinoma, CSCC: cutaneous squamous cell carcinoma. * as determined by the NCCN or AJCC criteria for high-risk CSCC.