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. 2020 May 30;12(6):1415. doi: 10.3390/cancers12061415

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic representation of β3-AR-regulated processes in tumor and stromal cells of melanoma microenvironment (TME). A complex network of interaction and crosstalk between tumor and stromal cells of the TME, sustained through β3-AR-enanched processes, promotes melanoma progression. (CAFs = cancer-associated fibroblast; ECM = extracellular matrix; HSCs = hematopoietic stem cells; M2 = macrophage type 2; MSCs = mesenchymal stem cells; SNS = sympathetic nervous system). Created with BioRender.