Table 1.

Central role of sirtuins in DNA repair, cell cycle control and mitochondria function (adapted from Meng et al. [34]).

	Localization	General Function	Function
SIRT1	Nucleus, Cytosol	DNA repair	Glucose metabolism, differentiation, insulin secretion, neuroprotection, vascular protection
SIRT2	Cytosol, Nucleus	Cell cycle	Adipose tissue development and functionality, blood glucose homeostasis, modulation of peripheral myelination
SIRT3	Mitochondria, Nucleus, Cytosol	Mitochondrial metabolism	ATP homeostasis, ROS detoxification, tumor suppression, DNA repair, neuroprotection, apoptosis suppression
SIRT4	Mitochondria	Mitochondrial metabolism	Insulin secretion, DNA repair, apoptosis suppression
SIRT5	Mitochondria, Cytosol, Nucleus	Mitochondrial metabolism	Urea cycle, ketone body formation, nitrogenous waste management, ROS detoxification
SIRT6	Nucleus (Chromatin)	DNA repair	Telomerase protection, genome stability, cholesterol homeostasis, glycolysis and gluconeogenesis
SIRT7	Nucleus (Nucleolus)	rRNA transcription, cell cycle	Cardiac protection