Figure 3.

EGFR tyrosine kinase inhibitors increase the apoptosis induced by VPA and doxorubicin. H28, M14K and ZL34 cells were treated with VPA, doxorubicin and/or an EGFR tyrosine kinase inhibitor (gefitinib or erlotinib) and were evaluated for their apoptotic response by an Annexin V assay. Data are expressed as the means ± SD. Comparisons of multiple groups were performed using one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison procedure. Data are from three independent experiments. * p-value < 0.05; ** p-value < 0.01; *** p-value < 0.001; NS: not significant.