Figure 3.

Regional PBB3 uptake with reference to the midbrain in familial Alzheimer’s disease with Osaka mutation (FAD (Osaka)), in early and advanced stage patients with sporadic Alzheimer’s disease (SAD) and healthy controls (HCs). Regions were set in the cerebellum (CBL), frontal cortex (FRC), lateral temporal cortex (LTC), posterior cingulate gyrus (PCG), precuneus (PC) and parietal cortex (PAR). In the cerebral cortex, PBB3 uptake in the FAD (Osaka) patient was higher than that in the HCs in all regions (>2.5 SD). PBB3 uptake was even higher than that in the early stage SAD patients and advanced stage SAD patients in the lateral temporal (>2 SD) and parietal cortices (>2.5 SD). Remarkably elevated PBB3 uptake in the cerebellum was found only in the FAD (Osaka) patient.