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. 2020 Jun 10;12(6):1521. doi: 10.3390/cancers12061521

Figure 1.

Figure 1

Ovarian cancer compression bioreactor schematic and computational model. (A) SolidWorks rendering of the compression bioreactor. Air is pumped into the underlying pressure chamber which deflects into the cancer cell laden interpenetrating hydrogel. The 3D cellular hydrogel component is held in place via a porous acrylic plug which also allows cell culture medium access from the top of this chamber; (B) Isometric view of a representative compression bioreactor; (C) Front view of a representative compression bioreactor with air pressure applied to demonstrate deflection of resistivity sensing membrane (black dome); (D) Mesh construction on COMSOL model of the hydrogel (1 cm height by 6 mm radius) and deflectable membrane (1 mm height by 6mm radius); (E) Sample output of COMSOL analysis showing center slice through z-y plane. Deformation of the membrane and hydrogel are shown with an applied pressure of 20 kPa. Average compressive stress within the hydrogel is 5.2 kPa.