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. 2020 Jun 15;12(6):1575. doi: 10.3390/cancers12061575

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cytotoxic activity of ABN401 in vitro and effect of ABN401 on MET signaling in MET-addicted cancer cells. (A) MET-addicted cancer cell lines and normal immortalized cells were treated with ABN401 for 72 h, and cell viability was assessed using the WST assay. Data are expressed as the mean ± standard deviation (SD) from three sextuplicate independent experiments. (B) SNU5, (C) Hs746T, (D) EBC-1, (E) SNU638, (F) H1993 cancer cell lines with MET protein overexpression and/or MET-high amplification and/or MET exon1 14 skipping treated with different concentrations of ABN401 for 72 h were harvested and examined by Western blotting. Western blotting data are representative of three independent experiments. Comparisons between the control (no treatment group) and treatment groups were performed using the t-test. ** p < 0.01.

Cytotoxic activity of ABN401 in vitro and effect of ABN401 on MET signaling in MET-addicted cancer cells. (A) MET-addicted cancer cell lines and normal immortalized cells were treated with ABN401 for 72 h, and cell viability was assessed using the WST assay. Data are expressed as the mean ± standard deviation (SD) from three sextuplicate independent experiments. (B) SNU5, (C) Hs746T, (D) EBC-1, (E) SNU638, (F) H1993 cancer cell lines with MET protein overexpression and/or MET-high amplification and/or MET exon1 14 skipping treated with different concentrations of ABN401 for 72 h were harvested and examined by Western blotting. Western blotting data are representative of three independent experiments. Comparisons between the control (no treatment group) and treatment groups were performed using the t-test. ** p < 0.01.