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. 2020 Jun 15;12(6):1575. doi: 10.3390/cancers12061575

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Pharmacokinetics of ABN401. Plasma concentration–time profiles of ABN401 following intravenous and oral administration in (A) SD rats, (B) beagle dogs, and (C) cynomolgus monkeys. The pharmacokinetic profiles including F% (bioavailability), C₀, C_max, T_max, T_1/2, AUC_0-t, and AUC_inf were measured after intravenous (IV) administration at 5 mg/kg and oral (P.O) administration at 5, 20, or 50 mg/kg in SD rats and IV at 2 mg/kg and oral administration at 2, 5, and 10 mg/kg in beagle dogs. In the cynomolgus monkeys, systemic exposure to ABN401 was detected after a single oral administration at 1, 5, and 10 mg/kg and after a single IV dose of 1 mg/kg.

Pharmacokinetics of ABN401. Plasma concentration–time profiles of ABN401 following intravenous and oral administration in (A) SD rats, (B) beagle dogs, and (C) cynomolgus monkeys. The pharmacokinetic profiles including F% (bioavailability), C₀, C_max, T_max, T_1/2, AUC_0-t, and AUC_inf were measured after intravenous (IV) administration at 5 mg/kg and oral (P.O) administration at 5, 20, or 50 mg/kg in SD rats and IV at 2 mg/kg and oral administration at 2, 5, and 10 mg/kg in beagle dogs. In the cynomolgus monkeys, systemic exposure to ABN401 was detected after a single oral administration at 1, 5, and 10 mg/kg and after a single IV dose of 1 mg/kg.