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MET status and IC50 value of ABN401 in MET-addicted cell lines.
| Name | q-PCR | c-MET IHC | MET FISH | ABN401 IC50 (nM) |
|
|---|---|---|---|---|---|
|
MET Copy Number Variation |
C | M | MET/CEP7 Ratio |
||
| SNU5 | 18.60 | 3 | 3 | >5 | 4.34 |
| Hs746T | 16.22 | 3 | 3 | >5 | 2.00 |
| MKN45 | 17.16 | 3 | 3 | >5 | 3.18 |
| SNU620 | 27.1 | 3 | 3 | >10 | 8.13 |
| SNU638 | 2.26 | 3 | 3 | 0.8 | 3.33 |
| EBC-1 | 17.25 | 3 | 3 | 2.31 | 2.22 |
| H1993 | 22.65 | 3 | 3 | 2.37 | 43.0 |
|
HFE145
(Negative cell line) |
1.07 | 0 | 0 | 1 | >10,000 |
C: Cytosol, M: Membrane.
