Table 4.
Quantitative Analysis of ABN401 in the plasma and tumor tissue in mice.
| Plasma | 10 mg/kg | 10 mg/kg | 30 mg/kg | 30 mg/kg |
| EBC-1 | SNU5 | EBC-1 | SNU-5 | |
| T1/2 (min) | 141 | 153 | 214 | 83.8 |
| Cmax (ng/mL) | 456 | 774 | 1170 | 1340 |
| AUCinf (ng·min/mL) | 193,000 | 200,000 | 527,000 | 554,000 |
| CL/F (mL/min/kg) | 51.8 | 50.0 | 56.9 | 54.1 |
| MRT (min) | 255 | 241 | 300 | 230 |
| Tumor | 10 mg/kg | 10 mg/kg | 30 mg/kg | 30 mg/kg |
| EBC-1 | SNU5 | EBC-1 | SNU-5 | |
| T1/2 (min) | 571 | 726 | 522 | 344 |
| Cmax (ng/mL) | 1260 | 1390 | 2950 | 2920 |
| AUCinf (ng·min/mL) | 715,000 | 553,000 | 2,240,000 | 1,470,000 |
T1/2 = terminal half-life, Cmax = maximum observed peak concentration, Tmax = time to reach Cmax, AUCinf = area under the time–concentration curve from zero to infinity, MRT = mean residence time, CL/F = oral clearance.