Figure 4.

The influence of experimental diets on the vasodilator response to acetylcholine in thoracic arteries isolated from WKYs (A,B) and SHRs (C,D). From 10 weeks of age, rats were fed a control diet without added raspberry seeds (RBS) (A,C) and with a diet supplemented for 6 weeks with added 7% ground RBS (B,D). ACh-induced vasodilation was analyzed in the absence and presence of nonselective cyclooxygenase (COX) inhibitor (indomethacin, 10 µM, 30 min), selective COX-2 inhibitor (NS-398, 10 µM, 30 min), and prostacyclin (PGI₂) synthesis inhibitor (tranylcypromine) TCP, 10 µM, 30 min). Results (mean ± SEM) are expressed as a percentage of the inhibition of the contraction induced by noradrenaline (1.5 ± 0.18 g), * p ≤ 0.05 (two-way ANOVA/Tukey’s), m = 6–8.