Figure 4.

Si306 and pro-Si306 suppress GBM cell lines invasion through the basement membrane. (a) Representative images of U87 and U87-TxR cells that invaded through matrigel to the opposite side of the membrane after 24 h treatment with 5 µM Si306 and pro-Si306. Scale bar = 200 µm. (b) Percentage of U87 and U87-TxR cells that invaded through matrigel and passed the membrane. Values are expressed as mean ± SEM (n = 3). C+ is positive control (with fetal bovine serum (FBS) as chemo-attractant) and C- is negative control (without chemo-attractant). Statistical significance compared to positive control group is shown as * (p < 0.05), ** (p < 0.01), and *** (p < 0.001).