Figure 4.

Schematic diagram presenting the possible mechanism of actions associated with anti-tumor activity, i.e.,: (i) localized heat produced at magnetosome location, either inside or outside cells depending on whether magnetosomes internalize in tumor cells or remain localized outside these cells, (ii) an apoptotic mechanism as highlighted when magnetosomes were brought into contact with U87-Luc cells and exposed to one magnetic session, (iii) mechanism of indirect tumor destruction involving magnetosomes covering the border of GBM tumor, and (iv) the attraction of immune cells (PNN) by the magnetosomes since PNN were observed near the magnetosomes in GBM tumors following a magnetic session although a direct link between the presence of PNN and the anti-tumor activity was not established.