Table 2.
Summarizes the in vitro and in vivo anti-tumor efficacies of the various nanomaterials presented in Table 1.
| Efficacy Results (In Vitro & In Vivo) of the Different Nanomaterials Presented in Table 1 |
References |
|---|---|
| cytotoxicity of NiO NP against HepG2 cancer cells (IC50 = 38 μg/mL) | [41], Abbasi 2019 |
| Cytoxicity of Pt NP against MCF-7, HCT-116, HepG-2 cells (90 < IC50 < 290 µg/mL) | [42], Al-Radad i2019 |
| Cytotoxicity of Pd NP towards A549 lung cancer cells No cytoxicity towards healthy peripheral lymphocytes |
[43], Anand 2016 |
| Pd NP have larger cytotoxicity toward human leukemia (MOLT-4) cells (IC50 = 0.006 μM) than tea extract (IC50 = 0.9 μM), doxorubicin (IC50 = 2 μM), or cisplatin (IC50 = 0.013 μM). NP relatively not cytotoxic towards healthy human fibroblast (HDF-a) cells. Cytotoxicity due to apoptosis/G2/M cell-cycle arrest NP have anti-oxydant activity |
[44], Azizi 2017 |
| Au NP anticancer activity against HeLa cells (through apoptosis) |
[45], Baharara 2016 |
| Cytotoxicity of ZnO NP towards Hep-G2 cells (ROS induce damage to DNA of the cells) |
[46], Chung 2015 |
| Cu NP are cytotoxic towards MCF-7 breast cancer cells | [47], Chung 2017 |
| Te NW (concentration between 5 and 100 μg/mL) improves healthy cell proliferation/decreases cancer cell growth. Higher efficacy compared with chemical Te NW. |
[48], Crua 2019 |
| Se NP cytotoxic towards HepG2 cells (IC50 = 19 µg/mL) NP produce ROS Cellular death through apoptosis |
[49], Cui 2018 |
| Cytotoxicity towards MCF-7 breast cancer cells of Ag NP (10 μg/mL) and PDT (0.5 mJ/cm2) Due to mitochondrial damage and intracellular ROS production |
[50], Erdogan 2019 |
| No CeO2 NP cytotoxicitys on periodental fibroblast cells. | [51], Kargar 2015 |
| Rosemary-FeNPs more cytotoxic towards 4T1 and C26 cancer cells than free Rosemary extract |
[52], Farschchi 2018 |
| Injection of magnetosomes in glioblastoma followed by several AMF applications leads to full tumor disappearance | [53], Alphandéry 2017 |
| Magnetosome cytotoxicity towards GBM RG-2 and GL-261 cells under the application of an AMF of 200 kHz and 40 mT. | [54], Hamdous 2017, 63, Mandawala 2017 |
| Au NP cytotoxic towards epidermoid carcinoma A431 cells upon laser irradiation laser at 800 nm (6 W/cm2). | [55], Fazal 2014 |
| Tb2O3 NP cytotoxic towards MG-63 and Saos-2 osteosarcoma cancer cells (IC50 = 0.102 μg/mL) Tb203 NP not cytotoxic towards primary osteoblasts up to 0.373 μg/mL. |
[56], Iram 2016 |
| Cytotoxicity of MgO NP towards A-549 human lung cancer cells (IC50 = 100 μg ml−1 after 24 h incubation) Less cytotoxicity of MgO NP twoards healthy vero cells (IC50 = 140 µg/mL) |
[57], Majeed 2018 |
| BaCO3 NP cytotoxic towards cervical carcinoma cells | [58], Nagajyothi 2016 |
| Possibility to add Curcumin at the surface of bismuth sulfide NP and to induce cytotoxicity towards HT-29 cells by release of CUR. | [59], Nosrati 2019 |
| Th NP cytotoxic towards A 375 melanoma cells. | [60], Pol 2018 |
| CdS QD cytotoxic towards A549 lung cancer cells. | [61], Shivaji 2018 |
| CoPt have better biocompatibility/lower toxicity than previously reported Co NP, Co@Au NP, and CoPt NP. → due to good biocompatibility/anti-oxidation potential of polyphenols that prevent cobalt release. |
[62], Song 2016 |
| MnO2 NP cytotoxic towards 4T1 breast cancer cells | [63], Chen 2016 |