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. 2020 Jun 26;21(12):4545. doi: 10.3390/ijms21124545

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Vasohibin-2 (VASH2) deficiency accelerated ischemia–reperfusion (I/R)-induced renal dysfunction and renal tubular injury. The increase in serum levels of blood urea nitrogen (BUN) (a) and creatinine (b) induced by I/R injury was higher in V2KO mice than WT mice; (c) light microscopy images of the renal corticomedullary areas (periodic acid-Schiff (PAS) staining, original magnification, ×200). (d) Acute tubular necrosis (ATN) score was calculated based on the percentage of damaged tubules. n = 6 for each group. * p < 0.01 vs. WT-cont, ^# p < 0.05 vs. WT-I/R. Each column shows the mean ± standard deviation (SD).