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. 2020 Jun 19;21(12):4369. doi: 10.3390/ijms21124369

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ABCA1^-B/-B-OPCs exhibit decreased migration compared to ABCA1^fl/fl-OPCs in vitro, while the treatment of ABCA1^-B/-B-OPCs with HDL3 or ApoE2 reversed the reduction of migration. Images of OPC-sphere cultures in ABCA1^fl/fl–OPCs (A), ABCA1^-B/-B-OPCs (B), and ABCA1^-B/-B-OPCs treated with HDL3 (C) or ApoE2 (D). The quantitative data of OPC migration distance (E) were acquired at 4 h or 10 h, respectively. * p < 0.05, vs. ABCA1^fl/fl-OPCs; ^, # p < 0.05, vs. ABCA1^-B/-B-OPCs; n = 6 wells/group.